ABSTRACT
Purpose. To compare diagnostic capabilities of antiXa and activated partial thromboplastin time (APTT) in monitoring low-molecular-weight heparin therapy. Materials and methods. To achieve the purpose of the study, a retrospective analysis of clinical and laboratory data of 20 patients who were hospitalized at the State Institution "Republican Clinical Medical Center" of the Administration of the President of the Republic of Belarus from September to December 2021 was carried out. The collection of laboratory data was carried out at the stage of hospitalization of patients with COVID-19 infection in inpatient departments. A total of 89 coagulograms were evaluated, including the levels of APTT, RAPTT and antiXa. Data are presented as median and interquartile range Me (Q1:Q3), mean and standard deviation (M±SD), and minimum (MIN) and maximum (MAX) values. Statistical analysis was performed using SPSS Statistics (IBM, USA) and Excel 2016 (Microsoft, USA) software packages. The level of statistical significance of the tests was determined by p<0.05. Results. Statistical analysis of coagulograms revealed that the mean and median values of aPTT did not reach the reference values being 32.89±9.65 sec and 30.1 (27.55;34.7), respectively. RAPTT in most samples did not reach the value of 1.5, and in 75% tests its level was less than 1.1. Linear regression analysis revealed that for coagulograms groups with antiXa levels ranging from 0.5 to 1.0 IU/ml and more than 1.0 IU/ml there was no linear relationship between APTT and antiXa values: the coefficients of determination R2 of the obtained prediction models were 0.0036 and 0.0649 respectively. At the same time, a linear regression model was obtained for the group of tests with antiXa levels up to 0.5 IU/ml, successfully predicting the results of coagulogram values in 38% of tests, indicating a closer relationship between aPTT and antiXa at low ranges of the latter, but the relation strength between values was not sufficient to reason about the high identity between the tests. Conclusion. Today we can say that the determination of the level of antiXa is an effective method for monitoring therapy with low molecular weight heparins. Although the APTT is a cheap and readily available test that is commonly used to monitor the use of unfractionated heparin, it cannot adequately control the target dosage of low molecular weight heparins. To date, it is reasonable to assume that the determination of antiXa levels is an effective method for monitoring low-molecular-weight heparin therapy. Although APTT is a low-cost and readily available test commonly used to monitor unfractionated heparin administration, it cannot provide adequate control of the target dosage of low-molecular-weight heparin. © 2022, Professionalnye Izdaniya. All rights reserved.